6-Chloromelatonin is a potent melatonin receptor agonist, a 5-methoxyindole compound that competes for presynaptic melatonin receptor sites in the rabbit retina, inhibiting the calcium-dependent release of [3H]dopamine with higher metabolic stability than melatonin. Chloromelatonin competitively binds to [3H]melatonin at MT2 receptors (pKi=9.77) and may be used to study insomnia and sleep disorders associated with depression.
Molekulargewicht:
266.72
Reinheit:
99.36%
CAS Nummer:
[63762-74-3]
Formel:
C13H15ClN2O2
Target-Kategorie:
Dopamine Receptor|||Melatonin Receptor
T22530
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