Quinacrine is a compound that is commonly used as an anti-protozoal agent. It inhibits voltage-dependent sodium channels (IC50: 3.3 µM) and suppresses aldehyde oxidase (IC50: 3.3 µM). Quinacrine prevents misfolding of prion protein (EC50: 0.3 µM). As an effective riboflavin antagonist, quinacrine associates with the riboflavin-binding protein (Ki: 6.7 µM). Voltage-dependent sodium channels play a vital role in action potential initiation and propagation in excitable cells, including muscle, nerve, and neuroendocrine cell types.
Molekulargewicht:
472.9
Formel:
C23H30ClN3O2HCl [XH2O]
Target-Kategorie:
Others
T23210
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