ABC1183 is a novel diaminothiazole that inhibits GSK3alpha, GSK3beta and CDK9. ABC1183 inhibits the growth of a numerous cancer cell lines by decreasing cell survival by inducing G2/M arrest and through altering GSK3, glycogen synthetase, beta-catenin phosphorylation and MCL1 expression,and is orally active.
Molekulargewicht:
334.39
Reinheit:
98.92%
CAS Nummer:
[1042735-18-1]
Formel:
C18H14N4OS
Target-Kategorie:
GSK-3|||CDK
T23601
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