Rubone (2-Hydroxy-2,4,4,5,6-pentamethoxychalcone), a natural product and a modulator of miR-34a (microRNA-34), upregulates miR-34a expression in a p53-dependent manner, which in turn downregulates the expression of downstream targets Bcl-2, cyclin-D1, CDK6, SIRT1, and FOXP1, thereby inhibiting tumor growth and reversal of hepatocellular carcinoma (HCC) and chemoresistance in prostate cancer.
Molekulargewicht:
374.38
Reinheit:
98.92%
CAS Nummer:
[73694-15-2]
Formel:
C20H22O7
Target-Kategorie:
MicroRNA
T24744
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