IMM-01 is a novel class of small-molecule agonists of the mammalian Diaphanous (mDia)-related formins, which act downstream of Rho GTPases to assemble actin filaments, and their organization with microfilaments to establish and maintain cell polarity during migration and asymmetric division. GTP-bound Rho activates mDia family members by disrupting the interaction between the DID and DAD autoregulatory domains, which releases the FH2 domain to modulate actin and microtubule dynamics[1].
Molekulargewicht:
267.35
Reinheit:
98.87%
CAS Nummer:
[218795-74-5]
Formel:
C12H17N3O2S
Target-Kategorie:
Ras|||Apoptosis|||GTPase
T25529
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