MS2177 is a potent and selective inhibitor of SETD8, the only methyltransferase known to catalyze monomethylation of histone H4 lysine 20 (H4K20). MS2177 has an in vitro IC50 of 1.9 µM (sigma = 1.05 µM, n = 4) in ascintillation proximity assay. Binding of MS2177 to SETD8 was confirmed by isothermal titration calorimetry (ITC), having a KD of 1.3 µM.
Molekulargewicht:
442.61
Formel:
C24H38N6O2
Target-Kategorie:
Others
T28114
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