5-Hydroxy-1-methylhydantoin, CAS [[84210-26-4]]

Produktübersicht

• Artikelname: 5-Hydroxy-1-methylhydantoin, CAS [[84210-26-4]]
• Artikelnummer: TGM-T28222
• Hersteller Artikelnummer: T28222
• Alternativnummer: TGM-T28222-1MLX10MM(INDMSO),TGM-T28222-5MG,TGM-T28222-10MG,TGM-T28222-25MG,TGM-T28222-50MG,TGM-T28222-100MG,TGM-T28222-200MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: HD-003 , HD003 , NZ419 , NZ-419 , HD 003 , NZ 419

Produktbeschreibung

5-Hydroxy-1-methylhydantoin (HD-003) is an antioxidant potentially for the treatment of renal failure. A creatinine metabolite, 5-Hydroxy-1-methylhydantoin , a hydroxyl radical scavenger, has previously been shown to confer renoprotection by inhibiting the progression of chronic kidney disease in rats. 5-Hydroxy-1-methylhydantoin is a novel anti-oxidant drug completely suppressed the expression of B2-kinin receptors (B2KR) in response to high glucose (25 mM) stimulation in VSMC and was also shown to attenuate the effects of BK on VSMC remodeling. 5-Hydroxy-1-methylhydantoin inhibited the BK-induced increase in MAPK phosphorylation and attenuated the increase in connective tissue growth factor (CTGF) protein levels in VSMC. These findings suggest that 5-Hydroxy-1-methylhydantoin may confer vascular protection against high glucose concentrations and BK-stimulation to ameliorate vascular injury and remodeling through its anti-oxidant properties.

Produkteigenschaften

• Molekulargewicht: 130.1
• Reinheit: 99.50%
• CAS Nummer: [84210-26-4]
• Formel: C4H6N2O3
• Target-Kategorie: Bradykinin Receptor|||ROS|||Reactive Oxygen Species

Bilder

T28222