SX-517 is a non-competitive dual antagonist of CXCR1/2, demonstrating anti-inflammatory effects in both PMN cells and mouse models. SX-517 inhibits CXCL-1-induced Ca flux (IC50 = 38 nM), antagonises CXCL-8-induced [(5)S]GTPgammaS binding (IC50 = 60 nM), and suppresses ERK1/2 phosphorylation.
Molekulargewicht:
382.22
Reinheit:
99.90%
CAS Nummer:
[1240494-13-6]
Formel:
C19H16BFN2O3S
Target-Kategorie:
CXCR
T28893
T28893
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