S49076 HCl, CAS [[1265966-31-1]]

Produktübersicht

• Artikelname: S49076 HCl, CAS [[1265966-31-1]]
• Artikelnummer: TGM-T3512
• Hersteller Artikelnummer: T3512
• Alternativnummer: TGM-T3512-5MG,TGM-T3512-10MG,TGM-T3512-25MG,TGM-T3512-50MG,TGM-T3512-100MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: S-49076 Hydrochloride

Produktbeschreibung

S49076 HCl (S-49076 Hydrochloride) is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 HCl potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream signaling in vitro and in vivo. In cell models, S49076 HCl inhibited the proliferation of MET- and FGFR2-dependent gastric cancer cells blocked MET-driven migration of lung carcinoma cells, and inhibited colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL. In tumor xenograft models, a good pharmacokinetic/pharmacodynamic relationship for MET and FGFR2 inhibition following oral administration of S49076 HCl was established and correlated well with impact on tumor growth.

Produkteigenschaften

• Molekulargewicht: 439.85
• CAS Nummer: [1265966-31-1]
• Formel: C22H18ClN3O5
• Target-Kategorie: c-Met/HGFR|||TAM Receptor|||FGFR

Bilder

T3512