Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. ()16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation. The biological activity of 16-HETE is stereospecific. 16(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, however 16(S)-HETE does not affect perfusion pressure. At a concentration of 2 µM the (S)-enantiomer of 16-HETE inhibits proximal tubule ATPase activity by as much as 60%, whereas the (R)-isomer has negligible effects on ATPase activity.
Molekulargewicht:
320.473
CAS Nummer:
[128914-46-5]
Formel:
C20H32O3
Target-Kategorie:
Others|||ATPase
T35465
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