()11(12)-EET, CAS [[123931-40-8]] Preis auf Anfrage

Produktübersicht

• Artikelname: ()11(12)-EET, CAS [[123931-40-8]] Preis auf Anfrage
• Artikelnummer: TGM-T35494
• Hersteller Artikelnummer: T35494
• Alternativnummer: TGM-T35494-1MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

()11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.[1][2][3] A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms CYP2C23 and CYP2C24, while CYP2B2 produces a higher proportion of 11(S),12(R)-EET.[3] 11(12)-EET has been shown, along with 8(9)-EET, to play a role in the recovery of depleted calcium pools in cultured smooth muscle cells.[4] It also inhibits basolateral 18-pS potassium channels in the renal cortical collecting duct at a concentration of 100 nM.[5] 11(12)-EET (50 µg/kg per day) increases adhesion of isolated peripheral blood leukocytes in a chamber coated with P-selectin and ICAM-1 but does not affect choroidal neovascularization size following laser photocoagulation.[6] It also has anti-inflammatory, angiogenic, and cardioprotective properties.[7]

Produkteigenschaften

• Molekulargewicht: 320.47
• CAS Nummer: [123931-40-8]
• Formel: C20H32O3
• Target-Kategorie: NOD-like Receptor (NLR)|||Others

Bilder

T35494