Gallocyanine is a synthetic azine-based blue dye and a potent inhibitor of DKK1/LRP6 interaction (IC50 = 6.38 µM). It selectively activates the Wnt signaling pathway by blocking the binding of DKK1 to its receptor LRP6, thereby inhibiting the antagonistic effects of this pathway and inducing intracellular beta-catenin accumulation. Gallocyanine exhibits antitumor metastasis, anti-inflammatory, and antifibrotic activities and can be used in research related to tumors, inflammatory injuries, and neurodegenerative diseases. Gallocyanine is a histological stain that specifically labels nucleic acids and cell nuclei, it can also serve as a biochemical fluorescent probe for the detection of superoxide anion radicals.
Molekulargewicht:
336.73
CAS Nummer:
[1562-85-2]
Formel:
C15H13ClN2O5
Target-Kategorie:
Wnt/beta-catenin
T35551
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