Migrastatin, CAS [[314245-65-3]]

Produktübersicht

• Artikelname: Migrastatin, CAS [[314245-65-3]]
• Artikelnummer: TGM-T35616
• Hersteller Artikelnummer: T35616
• Alternativnummer: TGM-T35616-1MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

Migrastatin is a bacterial metabolite that has been found inStreptomyceswith antimuscarinic and anticancer activities.1,2It binds to M1-5muscarinic acetylcholine receptors (Kis = >200, 200, 31, 43, and >200 µM, respectively) and inhibits calcium mobilization induced by carbamoylcholine in SK-N-SH cells (IC50= 28 µM), as well as in primary rat bladder smooth muscle cells.1Migrastatin inhibits the migration of EC17 esophageal cancer cells in a wound healing assay (IC50= 10 µg/ml) and 4T1 mouse mammary carcinoma cells in a chamber cell migration assay (IC50= 29 µM).2It enhances cytotoxicity induced by vinblastine in vincristine-resistant P388/VCR cells.3

Produkteigenschaften

• Molekulargewicht: 489.609
• CAS Nummer: [314245-65-3]
• Formel: C27H39NO7
• Target-Kategorie: Others|||Calcium Channel|||AChR

Bilder

T35616