4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized omega-6 polyunsaturated fatty acids such as arachidonic acid and linoleic acid. [1] [2] It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity and has been widely used as a marker of lipid peroxidation.[1][2][3] 4-oxo-2-Nonenal is a more recently identified product of lipid peroxidation.[4][5][6] It actively modifies histidine and lysine residues on proteins and causes protein cross-linking. [7][8] 4-oxo-2-Nonenal also modifies 2-deoxyguanosine, further implicating lipid peroxidation in mutagenesis and carcinogenesis.[4]
Molekulargewicht:
154.209
CAS Nummer:
[103560-62-9]
Formel:
C9H14O2
Target-Kategorie:
Others|||TRP/TRPV Channel
T35646
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