Collismycin A is a bacterial metabolite from *Streptomyces* with antibacterial, antiproliferative, and neuroprotective properties. It exhibits activity against various bacteria (MICs = 6.25-100 µg/ml) and fungi (MICs = 12.5-100 µg/ml). It inhibits proliferation of A549 lung, HCT116 colon, and HeLa cervical cancer cells (IC50s = 0.3, 0.6, and 0.3 µM, respectively) and NIH373 fibroblasts (IC50 = 56.6 µM) but not MDA-MD-231 breast cancer cells (IC50 > 100 µM). Collismycin A forms a complex with Fe(II) and Fe(III) in a 2:1 ratio, with iron ions inhibiting its antiproliferative effect on HeLa cells, an effect not observed with zinc, manganese, copper, or magnesium ions. Additionally, Collismycin A (1 µM) reduces apoptosis in zebrafish larvae brain regions by 44% in a model of neuronal cell death induced by all-trans retinoic acid.
Molekulargewicht:
275.33
CAS Nummer:
[158792-24-6]
Formel:
C13H13N3O2S
Target-Kategorie:
Others|||Antibacterial|||Apoptosis
T35687
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