Debutyldronedarone hydrochloride, CAS [[197431-02-0]]

Produktübersicht

• Artikelname: Debutyldronedarone hydrochloride, CAS [[197431-02-0]]
• Artikelnummer: TGM-T35712
• Hersteller Artikelnummer: T35712
• Alternativnummer: TGM-T35712-1MG, TGM-T35712-5MG, TGM-T35712-10MG, TGM-T35712-25MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: SR35021 hydrochloride

Produktbeschreibung

N-Desbutyl dronedarone is an active metabolite of the antiarrhythmic agent dronedarone .1,2,3It is formed from dronedarone by cytochrome P450s (CYPs) and monoamine oxidase (MAO) in human hepatocyte preparations.4N-Desbutyl dronedarone inhibits the binding of 3,3,5-triiodo-L-thyronine to the thyroid hormone receptors TRalpha1and TRbeta1(IC50s = 59 and 280 µM for the chicken and human receptors, respectively).1It inhibits CYP2J2-mediated formation of 14,15-EET from arachidonic acid and soluble epoxide hydrolase-mediated formation of 14,15-DHET from 14,15-EET (IC50s = 1.59 and 2.73 µM, respectively, in cell-free assays).2N-Desbutyl dronedarone decreases intracellular ATP levels in H9c2 rat cardiomyocytes (IC50= 1.07 µM) and inhibits mitochondrial complex I, also known as NADH dehydrogenase, and mitochondrial complex II, also known as succinate dehydrogenase, activities in isolated rat heart mitochondria (IC50s = 11.94 and 24.54 µM, respectively).3

Produkteigenschaften

• Molekulargewicht: 537.11
• CAS Nummer: [197431-02-0]
• Formel: C27H37ClN2O5S
• Target-Kategorie: Others|||Thyroid hormone receptor(THR)