Quinacrine is a compound with multiple actions that is commonly used as an anti-protozoal agent. It has also been shown to be a highly potent autophagy inhibitor, although the dose required to achieve this effect is considerably cytotoxic (LD50 = 2.5 µM). Quinacrine analog 34 is a derivative of quinacrine that was designed with an improved cell viability profile (LD50 = 27 µM) to inhibit autophagy. At a minimum concentration of 0.5 µM, this compound has been shown to increase the protein levels of the autophagy biomarker LC3-II and to induce lysosome deacidification.
Molekulargewicht:
358.91
Reinheit:
99.98%
CAS Nummer:
[1411646-44-0]
Formel:
C20H27ClN4
Target-Kategorie:
Others|||Autophagy
T35747
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