Trypacidin is a fungal metabolite originally isolated fromA. fumigatus.1It is active againstB. subtilisandM. bovis(MICs = 12.5 and 1.25 µg/ml, respectively), as well asT. cruziandT. gondii(MICs = 5-10 and 10-20 µg/ml, respectively).1,2It reduces viability and induces lysis of A549 human lung cancer cells (IC50s = 7.4 µM for both).3Trypacidin increases survival in a mouse model ofT. gondiiinfection when administered in six doses of 12.5 mg/kg each.1
Molekulargewicht:
344.319
CAS Nummer:
[1900-29-4]
Formel:
C18H16O7
Target-Kategorie:
Others|||Parasite
T35750
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