CAY10721 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (39% SIRT3 inhibition at 200 µM). Upregulation of SIRT3 transcription is associated with oral squamous cell carcinoma (OSCC) and breast cancer with lymph node involvement, while SIRT3 down-regulation inhibits the growth of OSCC cells and sensitizes them to radiation and chemotherapy.
Molekulargewicht:
351.38
CAS Nummer:
[848688-62-0]
Formel:
C18H13N3O3S
Target-Kategorie:
Sirtuin|||Others
T35821
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