CCG258208 hydrochloride (compound 14as hydrochloride) is a highly potent and selective G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 30 nM. It exhibits >200-fold selectivity for GRK2 over GRK5 (IC50 = 7.1µM). In cardiovascular research, CCG258208 effectively enhances the contractility of beta-AR-stimulated cardiomyocytes by inhibiting GRK2 activity. Additionally, the compound demonstrates excellent in vivo stability, making it a valuable tool for studying GRK2-related conditions such as heart failure.
Molekulargewicht:
488.94
Formel:
C24H26ClFN4O4
Target-Kategorie:
GRK
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
