p38 MAPK inhibitor IV is an ATP-competitive inhibitor of p38 MAP kinases with IC50 values of 0.13, 0.55, 5.47, and 8.63 µM for p38alpha, p38beta, p38x, and p38delta, respectively, in vitro.[1] It also inhibits LPS-induced TNF-alpha and IL-1beta cytokine production (IC50s = 22 and 44 nM, respectively) in human peripheral blood mononuclear cells.
Molekulargewicht:
456.94
CAS Nummer:
[1638-41-1]
Formel:
C12H4Cl6O4S
Target-Kategorie:
Others|||p38 MAPK
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