DS-7423, CAS [[1222104-37-1]]

Produktübersicht

• Artikelname: DS-7423, CAS [[1222104-37-1]]
• Artikelnummer: TGM-T36083
• Hersteller Artikelnummer: T36083
• Alternativnummer: TGM-T36083-1MLX10MM(INDMSO),TGM-T36083-1MG,TGM-T36083-5MG,TGM-T36083-10MG,TGM-T36083-25MG,TGM-T36083-50MG,TGM-T36083-100MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

DS-7423 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM and 34.9 nM for PI3Kalpha and mTOR, respectively, and exhibits anti-tumor activity[1][2]. It increases TP53 expression, the level of p-TP53 on Ser-46, and induces apoptosis-related TP53 target genes (TP53AIP1 and PUMA) in OCCC cells[1]. DS-7423 also inhibits other isoforms of class I PI3K with IC50 values of 1,143 nM for PI3Kbeta, 249 nM for PI3Kgamma, and 262 nM for PI3Kdelta[2]. [1]. Katsutoshi Oda, et al. Characterization of TP53 and PI3K signaling pathways as molecular targets in gynecologic malignancies. J Obstet Gynaecol Res. 2016 Jul,42(7):757-62. [2]. Tomoko Kashiyama, et al. Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423. PLoS One. 2014 Feb 4,9(2):e87220.

Produkteigenschaften

• Molekulargewicht: 520.51
• Reinheit: 99.68%
• CAS Nummer: [1222104-37-1]
• Formel: C22H27F3N10O2
• Target-Kategorie: mTOR|||PI3K

Bilder

T36083