RMC-5552 is a potent and selective inhibitor of mTORC1 that blocks phosphorylation of downstream signaling targets pS6K and p4EBP1 with IC50 values of 0.14 nM and 0.48 nM, respectively. RMC-5552 shows markedly reduced inhibition of pAKT (IC50 19 nM), achieving approximately 40-fold selectivity for mTORC1 over mTORC2. RMC-5552 has demonstrated anticancer activity, supporting its potential use as a therapeutic agent in oncology and as a research tool for dissecting mTOR signaling pathways.
Molekulargewicht:
1778.16
CAS Nummer:
[2382768-62-7]
Formel:
C93H136N10O24
Target-Kategorie:
mTOR
T36089
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