K-TMZ, CAS [[2269482-26-8]]

Produktübersicht

• Artikelname: K-TMZ, CAS [[2269482-26-8]]
• Artikelnummer: TGM-T36100
• Hersteller Artikelnummer: T36100
• Alternativnummer: TGM-T36100-1MG,TGM-T36100-5MG,TGM-T36100-10MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

K-TMZ is a DNA alkylating agent. It increases the concentration of O6-methylated deoxyguanosine in U87 glioblastoma multiforme (GBM) cells in a concentration-dependent manner. K-TMZ reduces cell viability of GBM cell lines lacking (IC50s = 18-44 µM) or expressing O6-methylguanine DNA methyltransferase (MGMT, IC50s = 115-240 µM). K-TMZ can cross the blood-brain barrier and increases survival in a Br23c mouse xenograft model of GBM when administered at a dose of 14.9 mg/kg.

Produkteigenschaften

• CAS Nummer: [2269482-26-8]
• Target-Kategorie: Others