Citrulline-specific Probe-Rhodamine, CAS [[2309313-01-5]]

Produktübersicht

• Artikelname: Citrulline-specific Probe-Rhodamine, CAS [[2309313-01-5]]
• Artikelnummer: TGM-T36104
• Hersteller Artikelnummer: T36104
• Alternativnummer: TGM-T36104-1MG,TGM-T36104-250UG,TGM-T36104-500UG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

Protein arginine deiminases (PADs) catalyze the posttranslational modification of arginine residues on proteins to form citrulline, which plays a large role in regulating gene expression. Abnormally high PAD activity has been observed in a host of human diseases. Citrulline-specific probe-rhodamine is a highly sensitive, rhodamine phenylglyoxal-based fluorophore that specifically detects protein citrullination via a chemoselective reaction between glyoxal and citrulline. This chemical probe (comprised of a single isomer) is capable of reacting with any citrulline-containing protein and can be analyzed with fluorescent imaging (excitation 532 nm, emission 580 nm). When added at 100 µM for 30 minutes at acidic pH, this probe has a reported limit of detection of ~10 ng for citrullinated histone H3 and ~1 ng for autodeiminated PAD4.

Produkteigenschaften

• Molekulargewicht: 731.75
• CAS Nummer: [2309313-01-5]
• Formel: C39H37N7O8
• Target-Kategorie: Others

Bilder

T36104