20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This omega-oxidation conversion can take place using purified alcohol dehydrogenases three and four or by microsomes containing recombinant human CYP4F3B. Like 20-HETE, 20-COOH-AA inhibits ion transport in the kidneys. It also produces vasorelaxation of porcine coronary microvessels constricted with endothelin. 20-COOH-AA binds to isolated ligand binding domains of peroxisome proliferator-activated receptor alpha (PPARalpha) (Kd = 0.87 0.12 µM) and PPARgamma (Kd = 1.7 0.5 µM), and is a dual activator of PPARalpha and PPARgamma in a transiently transfected COS-7 cell reporter system.
Molekulargewicht:
334.456
CAS Nummer:
[79551-84-1]
Formel:
C20H30O4
Target-Kategorie:
PPAR|||Others
T36232
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