Rhein-13C4, CAS [[1189928-10-6]] Preis auf Anfrage
Artikelnummer:
TGM-T36408
Hersteller Artikelnummer:
T36408
Alternativnummer:
TGM-T36408-1MG
Hersteller:
TargetMol
Kategorie:
Biochemikalien
Alternative Synonym:
Rhein-13C4
Rhein-13C4 is intended for use as an internal standard for the quantification of rhein by GC- or LC-MS. Rhein (T2997) is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerein . At 10 µM, rhein inhibits IL-1beta signaling, suppressing signaling through NF-kappaB, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13.1 It inhibits IKKbeta (IC50 = 11.8 µM), decreasing iNOS and IL-6 expression in LPS-stimulated macrophages but paradoxically increasing TNF-alpha, IL-1beta, and HMBG1 expression.2 Rhein (T2997) shows efficacy against pancreatic fibrosis, chronic pancreatitis, and hyperglycemia-induced pancreatic beta-cell apoptosis.3,4 It also inhibits angiogenesis of breast cancer cells under normoxic and hypoxic conditions.5
