CMC2.24 (TRB-N0224) is an orally active tricarbonylmethane agent that demonstrates effectiveness in inhibiting Ras activation and the downstream effector ERK1/2 pathway, thus effectively combating pancreatic tumor formation in mice. Additionally, CMC2.24 exerts potent inhibitory effects on zinc-dependent MMPs, with IC50s ranging from 2.0-69 µM. Furthermore, CMC2.24 aids in alleviating the progression of osteoarthritis by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis through the NF-kappaB/HIF-2alpha axis[1][2][3].
Molekulargewicht:
427.45
CAS Nummer:
[1255639-43-0]
Formel:
C26H21NO5
Target-Kategorie:
Apoptosis|||Ras|||MMP|||Others
T36492
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