Ganglioside GT1b Mixture (sodium salt), CAS [[59247-13-1]]

Produktübersicht

• Artikelname: Ganglioside GT1b Mixture (sodium salt), CAS [[59247-13-1]]
• Artikelnummer: TGM-T36862
• Hersteller Artikelnummer: T36862
• Alternativnummer: TGM-T36862-1MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: Ganglioside GT1b Mixture (sodium salt) , Ganglioside G1 Mixture

Produktbeschreibung

Ganglioside GT1b is a trisialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit. It binds to the neurotoxins botulinum toxin serotype A (BTxA), BTxA heavy chain, and tetanus toxin with IC50 values of 11, 0.74, and 7.2 µM, respectively.[1] Ganglioside GT1b-containing liposomes bind to the major coat protein VP1 from Merkel cell polyomavirus (MCPyV), which has been identified in Merkel cell carcinomas, identifying ganglioside GT1b as a putative MCPyV receptor. [2] Ganglioside GT1b decreases production of IL-6, IL-10, IgG, IgM, and IgA in human peripheral blood mononuclear cells (PBMCs) by 31.4, 30.5, 60, 59.5, and 58%, respectively, when used at a concentration of 10 µM [3] . Ganglioside GT1b mixture contains ganglioside GT1b molecular species with C18:1 and C20:1 sphingoid backbones.

Produkteigenschaften

• Molekulargewicht: 2195.27
• CAS Nummer: [59247-13-1]
• Formel: C95H162N5O473Na
• Target-Kategorie: Others