S65487 (VOB560) is a potent and selective inhibitor of the anti-apoptotic protein Bcl-2, displaying activity not only against the wild-type protein but also against clinically relevant BCL-2 mutations such as G101V and D103Y. S65487 demonstrates poor affinity toward other Bcl-2 family members, including MCL-1, BFL-1, and BCL-XL, which underlines its selectivity profile. S65487 induces apoptosis in cancer cells and exhibits robust anticancer activities in preclinical studies.
Molekulargewicht:
717.26
Reinheit:
99.03%
CAS Nummer:
[1644600-79-2]
Formel:
C41H41ClN6O4
Target-Kategorie:
Apoptosis|||Bcl-2 Family|||Others
T36897
T36897
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