PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a regulator of ferroptosis. GPX4 activity was increased to 150% of control levels when used at a concentration of 20 µM in a cell-free assay, and at a concentration of 61 µM in wild-type, but not Gpx4-/-, mouse embryonic fibroblast (MEF) extracts.PKUMDL-LC-101-D04 (200 µM) reduced cholesterol peroxide-induced MEF death.
Molekulargewicht:
378.94
Reinheit:
99.65%
CAS Nummer:
[2143896-83-5]
Formel:
C14H23ClN4O2S2
Target-Kategorie:
Glutathione Peroxidase|||GPX
T36935
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