Pyridomycin is a structurally unusual antimycobacterial cyclodepsipeptide whose composition includes two rare moieties: 3-(3-pyridyl)-L-alanine and 2-hydroxy-3-methylpent-2-enoic acid. It inhibits NADH-dependent enoyl (Acyl-Carrier-Protein) reductase InhA, preventing mycolic acid synthesis in M. tuberculosis, including isoniazid-resistant strains (MICs = 0.31-0.63 µg/ml).
Molekulargewicht:
540.57
CAS Nummer:
[18791-21-4]
Formel:
C27H32N4O8
Target-Kategorie:
Antibacterial|||Others|||Antibiotic
T37070
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