Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms A, C, and D. VEGFR2 kinase inhibitor II is a reversible, cell-permeable inhibitor of VEGFR2s kinase activity (IC50 = 70 nM). It less potently inhibits the platelet-derived growth factor receptor beta (PDGFRbeta, IC50 = 920 nM) and related receptor and non-receptor tyrosine kinases. VEGFR2 kinase inhibitor II blocks the growth of human umbilical vein endothelial cells stimulated with either VEGF or PDGF (IC50s = 110 nM and 2 µM, respectively).
Molekulargewicht:
343.22
CAS Nummer:
[288144-20-7]
Formel:
C17H15BrN2O
Target-Kategorie:
Others|||PDGFR|||VEGFR
T37079
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