Docosahexaenoic acid is a nutritionally-derived omega-3 fatty acid that is abundant in the brain and the retina and is thought to be important in early development and for therapeutic approaches to inflammatory disorders and cancer. 14(S)-HDHA is an oxygenation product of DHA that serves as a precursor to maresin 1 , an anti-inflammatory, pro-resolving mediator that prevents polymorphonuclear neutrophil (PMN) infiltration and stimulates macrophage phagocytosis. At doses as low as 0.2 ng/mouse 14(S)-HDHA administration resulted in reduced infiltration of PMNs into sites of inflammation.
Molekulargewicht:
344.49
CAS Nummer:
[119433-37-3]
Formel:
C22H32O3
Target-Kategorie:
Others|||Drug Metabolite
T37259
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