14,15-Leukotriene D4, CAS [[75290-64-1]]

Produktübersicht

• Artikelname: 14,15-Leukotriene D4, CAS [[75290-64-1]]
• Artikelnummer: TGM-T37261
• Hersteller Artikelnummer: T37261
• Alternativnummer: TGM-T37261-25UG,TGM-T37261-50UG,TGM-T37261-100UG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: 14,15-Leukotriene D4

Produktbeschreibung

14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. 14,15-LTD4 is classified as an eoxin (EXD4), because it is formed mostly by eosinophils. However, mast cells and nasal polyps can synthesize 14,15-LTD4 as well. Little is known about the physiological actions of 14,15-LTD4. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs. However, in an in vitro permeability assay, 14,15-LTD4 can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs, resulting in plasma leakage, a hallmark of inflammation.

Produkteigenschaften

• Molekulargewicht: 496.66
• CAS Nummer: [75290-64-1]
• Formel: C25H40N2O6S
• Target-Kategorie: Others|||Endogenous Metabolite

Bilder

T37261