BLX3887 is an inhibitor of 15-lipoxygenase type 1 (15-LO-1, IC50 = 32 nM in a cell-free enzyme assay).1 It is selective for 15-LO-1 over 15-LO-2, which it does not inhibit, 5-LO (IC50 = 472 nM), and 12-LO (IC50 = 3,310 nM). BLX3887 inhibits the production of 15-LO metabolites selectively in eosinophils over neutrophils when used at a concentration of 10 µM. It also inhibits endocytosis in, and the migration of, isolated human peripheral blood mononuclear cell-derived dendritic cells in vitro.
Molekulargewicht:
308.52
CAS Nummer:
[934758-70-0]
Formel:
C10H5Cl3FN3O
Target-Kategorie:
Lipoxygenase|||Others
T37273
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