BLX3887 is a highly potent and selective inhibitor of 15-lipoxygenase type 1 (15-LO-1), exhibiting an IC50 of 32 nM in cell-free enzyme assays, with marked selectivity over 15-LO-2, which it does not inhibit, as well as over 5-LO (IC50 = 472 nM) and 12-LO (IC50 = 3,310 nM). BLX3887 selectively suppresses 15-LO metabolite production in eosinophils over neutrophils at 10 µM while additionally inhibiting endocytosis and migration of human peripheral blood mononuclear cell-derived dendritic cells in vitro, highlighting its utility in inflammatory and immune cell signaling research.
Molekulargewicht:
308.52
CAS Nummer:
[934758-70-0]
Formel:
C10H5Cl3FN3O
Target-Kategorie:
Lipoxygenase
T37273
T37273
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
