5beta-Dihydroprogesterone (5beta-DHP) is a progesterone receptor agonist and metabolite of progesterone .1,2It is formed from progesterone by 5beta-reductase.25beta-DHP inhibits spontaneous contractions in isolated rat uterus when used at a concentration of 10 µg/ml, an effect that can be blocked by the progesterone receptor antagonist RU486 but not the GABAAreceptor antagonist picrotoxin .1It is a negative modulator of homooligomeric Ρ1 subunit-containing GABAAreceptors, inhibiting GABA-induced currents inX. laevisoocytes expressing these receptors (IC50= 5.02 µM).3Plasma levels of 5beta-DHP decrease at the onset of spontaneous human labor.4
Molekulargewicht:
316.485
CAS Nummer:
[128-23-4]
Formel:
C21H32O2
Target-Kategorie:
Others|||Oxytocin Receptor
T37319
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