RN-9893 is an antagonist of transient receptor potential vanilloid 4 (TRPV4, IC50s = 0.42 and 0.66 µM, respectively, for the human and rat receptors).1 It is selective for TRPV4 over TRPV1, TRPV3, and TRPM8 (IC50s = 10, >30, and 30 µM, respectively). RN-9893 reduces rat TRPV4 activity induced by 4alpha-phorbol 12,13-didecanoate or hypotonicity (IC50s = 0.57 and 2.1 µM, respectively, in cell free assays).
Molekulargewicht:
536.95
CAS Nummer:
[2109450-40-8]
Formel:
C21H24ClF3N4O5S
Target-Kategorie:
Others|||TRP/TRPV Channel
T37321
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