5-Hydroxytoluene-2,4-disulphonic acid diammonium, an impurity of Policresulen, is a significant NS2B/NS3 protease inhibitor with an IC50 value of 0.48 µg/mL. It effectively inhibits DENV2 virus replication in BHK-21 cells, with an IC50 of 4.99 µg/mL. Policresulen acts as a competitive inhibitor, marginally impacting the proteases stability[1].
Target-Kategorie:
Virus Protease|||Others
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