6beta-hydroxy Dexamethasone is a metabolite of dexamethasone that is more hydrophilic than the parent compound. Dexamethasone is metabolized by CYP3A4, therefore, quantification of the dexamethasone metabolites, 6alpha- and 6beta-hydroxy dexamethasone, can be used to determine CYP3A4 enzyme activity in humans., The formation of 6-hydroxy dexamethasone metabolites is species-specific, with hamsters producing the highest amount. In rats, dexamethasone hydroxylation is sex-specific, with male rats producing metabolites in similar ratios to humans and female rats producing fewer hydroxylated metabolites than male rats.
Molekulargewicht:
408.46
CAS Nummer:
[55879-47-5]
Formel:
C22H29FO6
Target-Kategorie:
Others|||Glucocorticoid Receptor
T37361
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