Amyloid-beta (1-42) (Abeta42) is a neurotoxic 42-amino acid protein fragment found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimers disease.1,2,3Aggregation of Abeta42 results in the formation of neurotoxic fibrils or globular oligomers.1Abeta42 accumulates in the brain of many transgenic mouse models of Alzheimers disease and, in many models, the onset of amyloid deposition positively correlates with deficits in spatial learning and memory.4
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