C18 Globotriaosylceramide (d18:1/18:0), CAS [[69283-33-6]]

Produktübersicht

• Artikelname: C18 Globotriaosylceramide (d18:1/18:0), CAS [[69283-33-6]]
• Artikelnummer: TGM-T37439
• Hersteller Artikelnummer: T37439
• Alternativnummer: TGM-T37439-500UG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

C18 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from lactosylceramide . It inhibits aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate (PMA, 10008014) when used at a concentration of 1 µM. C18 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry disease, a lysosomal storage disorder characterized by a deficiency in the enzyme alpha-galactosidase A. C18 globotriaosylceramide also accumulates in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease.

Produkteigenschaften

• Molekulargewicht: 1052.391
• CAS Nummer: [69283-33-6]
• Formel: C54H101NO18
• Target-Kategorie: Others