Amycolatopsin C is a polyketide macrolide originally isolated fromAmycolatopsisthat has antimycobacterial and anticancer activities.1It is active againstM. bovisandM. tuberculosis(IC50s = 2.7 and 5.7 µM, respectively) but notB. subtilis,S. aureus,E. coli, orP. aeruginosa(IC50s = >30 µM for all). Amycolatopsin C is cytotoxic to SW620 colorectal and NCI H460 lung cancer cells (IC50s = 10 and 5.9 µM, respectively).
Target-Kategorie:
Antibiotic|||Others|||Antibacterial
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