Pericosine A is a fungal metabolite that has been found inP. byssoidesand has anticancer activity.1It inhibits the growth of a variety of cancer cells, including breast, colon, lung, ovary, stomach, and prostate cell lines (GI50s = 0.05-24.55 µM) and increases survival in a P388 mouse xenograft model when administered at a dose of 25 mg/kg. Pericosine A inhibits EGFR by 40 to 70% when used at a concentration of 100 µg/ml. It also reacts with organosulfur compounds in skunk spray to form stable thioethers as odorless products.2
Molekulargewicht:
222.62
CAS Nummer:
[200335-68-8]
Formel:
C8H11ClO5
Target-Kategorie:
Topoisomerase|||Others
T37594
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