Docosapentaenoic acid (DPA) is a omega-3 fatty acid found in fish oils. 17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DPA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARgamma agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 µM).
Molekulargewicht:
344.495
CAS Nummer:
[1233715-33-7]
Formel:
C22H32O3
Target-Kategorie:
Others|||PPAR|||NF-kappaB
T37634
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