Potent and selective beta-secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays >5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin and renin. Inhibits Abeta1-40 and Abeta1-42 production in cells expressing mutated APP. Reduces hippocampal and cortical Abeta and sAPPbeta levels in an Alzheimers disease mouse model.
Molekulargewicht:
426.87
CAS Nummer:
[1262036-49-6]
Formel:
C18H17ClF2N4O2S
Target-Kategorie:
Others|||Beta-Secretase
T37661
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
