STING agonist 1a is an agonist of stimulator of interferon genes (STING).1It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50= 16.77 µM). STING agonist 1a (12.5-100 µM) induces expression of IFN-beta, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 .
Molekulargewicht:
396.23
Reinheit:
98.07%
CAS Nummer:
[652142-94-4]
Formel:
C19H11Cl2N5O
Target-Kategorie:
Others|||STING
T38160
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