Prostaglandin D2 is synthesized by hematopoietic-type PGD-synthase (H-PGDS) in mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. PGD2 is also produced in the brain by lipocalin-PGD-synthase also known as beta-trace. In the brain, PGD2 produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. tetranor-PGDM is a major metabolite of PGD2 that is detectable in human and mouse urine. The levels of tetranor-PGDM and 2,3-dinor-11beta-PGF2alpha , a related PGD2 metabolite, in human urine were found to be 1.5 0.3 and 0.6 ng/mg creatinine, respectively. tetranor-PGDM was detected in murine urine at a level of 8.1 1.3 ng/mg creatinine.
Molekulargewicht:
328.361
CAS Nummer:
[70803-91-7]
Formel:
C16H24O7
Target-Kategorie:
Others|||Prostaglandin Receptor
T38306
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