CU-76 is an inhibitor of cyclic GMP-AMP synthase (cGAS, IC50= 0.24 µM).1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. CU-76 decreases IFN-stimulatory DNA-induced production of IFN-beta in THP-1 cells when used at concentrations of 10, 30, and 100 µM.
Molekulargewicht:
407.11
CAS Nummer:
[2400954-58-5]
Formel:
C11H8F2IN5O2
Target-Kategorie:
Others|||cGAS
T38329
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