GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor that inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling with an IC50 of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells[1]. It blocks the synergy between NOD2 and TLR2 without affecting NOD1, TNFR1, and TLR2-mediated responses. At 5 µM, GSK717 inhibits the release of IL-8, IL-6, TNFalpha, and IL-1beta in primary human monocytes stimulated with MDP[1]. [1]. Rickard DJ, et al. Identification of benzimidazole diamides as selective inhibitors of the nucleotide-binding oligomerization domain 2 (NOD2) signaling pathway. PLoS One. 2013,8(8):e69619. Published 2013 Aug 1.
Molekulargewicht:
452.55
Reinheit:
97.34%
CAS Nummer:
[1595278-21-9]
Formel:
C28H28N4O2
Target-Kategorie:
NOD-like Receptor (NLR)|||NOD|||IL Receptor
T38361
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